2,4-Dinitrophenol (2,4-DNP)

2,4-Dinitrophenol (2,4-DNP), High-Purity Laboratory Grade

Elevate your biochemical and synthetic research with our premium-grade 2,4-Dinitrophenol, a versatile and essential tool for advanced laboratory investigations. Supplied as a high-purity crystalline solid (≥99% purity, wetted with water for safety and stability), this compound is sourced and prepared specifically for research institutions, universities, and industrial R&D labs seeking reliable, consistent performance.

Key Research Applications

2,4-DNP is a classic mitochondrial uncoupler widely used in cellular bioenergetics studies to investigate oxidative phosphorylation, proton gradients, and metabolic regulation. Researchers rely on it for:

• Mitochondrial function and ROS studies — Probing energy metabolism, reactive oxygen species production, and calcium handling in models of metabolic diseases, neurodegeneration, and aging.
• Immunoassays and detection systems — Serving as an effective hapten in biotin-free assay designs, oxidative damage visualization, and control reagents for in vitro diagnostics.
• Chemical synthesis and analytical chemistry — As an intermediate in the preparation of dyes, photochemicals, and specialized derivatives; also useful as a pH indicator in select applications.
• Environmental and materials research — Supporting studies on pollutant degradation, wood preservatives, herbicides, and explosive-related chemistry (as a reference standard or byproduct analog).

Its unique ability to uncouple oxidative phosphorylation makes it a gold-standard reagent for dissecting mitochondrial physiology in controlled experimental settings.

Product Highlights

• High purity suitable for sensitive biochemical assays and organic synthesis.
  
• Wetted with >15% water content to ensure stability and compliance with safety standards.
• Reliable supply chain for ongoing research programs — batch-to-batch consistency you can trust.

Important Safety and Handling Information

2,4-Dinitrophenol is a potent chemical with significant hazards and must be handled exclusively by trained laboratory personnel in approved research facilities. It is toxic, can cause hyperthermia through metabolic uncoupling, and poses explosion risks if allowed to dry out.

Proper Safe Handling Procedures:

• Personal Protective Equipment (PPE): Always wear chemical-resistant gloves, lab coat, safety goggles or face shield, and appropriate respiratory protection if dust generation is possible.
• Work Environment: Use exclusively in a certified chemical fume hood. Avoid dust formation and inhalation. Do not eat, drink, or smoke in the handling area.
• Storage: Keep in a tightly closed container, cool, dry, well-ventilated place away from heat, sparks, flames, and incompatible materials (strong bases, oxidizers). Maintain moisture content — never allow material to dry completely. Store locked up and accessible only to authorized personnel.
• Handling Precautions: Use non-metallic (e.g., plastic or ceramic) spatulas. Re-wet with water if needed. Avoid shock, friction, or heating. Wash thoroughly after handling and change contaminated clothing immediately.
• Emergency Response: In case of exposure (skin, eyes, inhalation), seek immediate medical attention. For spills or fire, follow institutional protocols.
• Regulatory Note: This product is sold strictly for research and laboratory use only. It is not for human or animal consumption, therapeutic use, or any non-research application. Compliance with all local, state, and federal regulations (including controlled substances or hazardous materials requirements) is the responsibility of the purchaser.

Specifications:

Synonym: α-Dinitrophenol, 2,4-DNP, DNP

Safety Information:

Danger! Flammable solid. Fatal if swallowed. Toxic in contact with skin or if inhaled. Causes damage to organs through prolonged or repeated exposure. Very toxic to aquatic life.

DOT: UN1320, Dinitrophenol, wetted, 4.1 (6.1), PG I

Additional Information:

The product is being supplied under the TSCA R&D Exemption (40 CFR Section 720.36). It is the recipient’s responsibility to comply with the requirements of the R&D exemption.